Publications

Recent Talks & Posters

Harvard Symposium 2024

Untamed Immunity: Using “Dirty” Mice as a New Paradigm for Translatable Trauma Immunology Research

Shock Society 2023

Functional mass cytometry (CyTOF) shows perturbed phosphosignaling phenotypes in neutrophils and monocytes in whole blood from sepsis patients

Society for Leukocyte Biology 2022

Treg enrichment in a mouse injury model restores immune responses and survival to bacterial infection by modulating inflammation and organ injury

Natural immune mice show immune phenotypes consistent with acquired trained immunity and will provide new opportunities for “transitional translational” research addressing human diseases

Paracrine factors from mesenchymal stromal cells mediate trained immunity by epigenetic and mTOR signaling pathway modifying effects on hematopoietic stem cells

Publications

Guo F, Hancock B, Griffith A, Lin H, Howard K, Keegan J, Zhang F, Chicoine A, Cahill L, Ng J, Lederer J. Distinct Injury Responsive Regulatory T Cells Identified by Multi-Dimensional Phenotyping. Front Immunol. 2022 May 12;13:833100. doi: 10.3389/fimmu.2022.833100. PMID: 35634302; PMCID: PMC9135044.

JW Keegan, F Borriello, SM Fernandes, JR Brown, JA Lederer. Engineered immunostimulatory cells can convert PBMCs from chronic lymphocytic leukemia (CLL) patients into potent tumor killing immune cells. Journal of Clinical Oncology. 2021; 39 (15_suppl), 7517-7517.

L Cahill, F Guo, F Zhang, J Ng, A Griffith, K Howard, J Keegan, J Lederer. Increased regulatory T cells suppress traumatic injury induced inflammation and control adaptive immune cell expansion in an experimental model of burn trauma. The Journal of Immunology. 2020;  204 (1 Supplement), 228.5-228.5.

Seshadri A, Brat GA, Yorkgitis BK, Giangola M, Keegan J, Nguyen J, Li W, Nakahori Y, Wada T, Salim A, Askari R, Lederer J. Altered Monocyte and NK Cell Phenotypes Correlate with Post-Trauma Infection. Journal of Trauma and Acute Care Surgery. (2019).

 

Seshadri A, Brat GA, Yorkgitis BK, Keegan J, Dolan J, Salim A, Askari R, Lederer JA. Phenotyping the Immune Response to Trauma: A Multiparametric Systems Immunology Approach. Critical Care Medicine. 2017; 45(9): 1523-1530.

 

Wanke-Jellinek L, Keegan JW, Dolan JW, Lederer JA. Characterization of lung infection-induced TCRγδ T cell phenotypes by CyTOF mass cytometry. Journal of Leukocyte Biology. 2016; 99(3):483-93.

 

Wanke-Jellinek L, Keegan JW, Dolan JW, Guo F, Chen J, Lederer JA. Beneficial effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection. Journal of Immunology. 2016; 196(2):767-77.

 

Stoecklein VM, Osuka A, Ishikawa S, Lederer MR, Wanke-Jellinek L, Lederer JA. Radiation exposure induces inflammasome pathway activation in immune cells. Journal of Immunology. 2015; 194(3):1178-89.

 

Shay T, Lederer JA, Benoist C. Genomic responses to inflammation in mouse models mimic humans: we concur, apples to oranges comparisons won’t do. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(4):E346.

 

Yamaguchi T, Calvacanti BM, Cruzat A, Qazi Y, Ishikawa S, Osuka A, Lederer J, Hamrah P. Correlation between human tear cytokine levels and cellular corneal changes in patients with bacterial keratitis by in vivo confocal microscopy. Investigative Ophthalmology & Visual Science. 2014; 55(11):7457-66.

 

Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm reprogramming during lung inflammation. Nature Communications. 2014; 5:4753.

 

Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann  C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock. 2014; 41(6):463-75.

 

Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014; 145(3):454-63.

 

Hall SR, Tsoyi K, Ith B, Padera RF Jr, Lederer JA, Wang Z, Liu X, Perrella MA. Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013; 31(2):397-407.

 

Tajima G, Delisle AJ, Hoang K, O’Leary FM, Ikeda K, Hanschen M, Stoecklein VM, Lederer JA. Immune system phenotyping of radiation and radiation combined injury in outbred mice. Radiation Research. 2013; 179(1):101-12.

 

Stoecklein VM, Osuka A, Lederer JA. Trauma equals danger–damage control by the immune system. Journal of Leukocyte Biology. 2012; 92(3):539-51.

 

Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. American Journal of Respiratory Cell and Molecular Biology. 2012; 47(2):209-17.

 

Hanschen M, Tajima G, O’Leary F, Hoang K, Ikeda K, Lederer JA. Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells. Journal of Immunological Methods. 2012; 376(1-2):1-12.

 

Osuka A, Hanschen M, Stoecklein V, Lederer JA. A protective role for inflammasome activation following injury. Shock. 2012; 37(1):47-55.

 

Byrne WL, Mills KH, Lederer JA, O’Sullivan GC. Targeting regulatory T cells in cancer. Cancer Research. 2011; 71(22):6915-20.

 

O’Leary FM, Tajima G, Delisle AJ, Ikeda K, Dolan SM, Hanschen M, Mannick JA, Lederer JA. Injury-induced GR-1+ macrophage expansion and activation occurs independently of CD4 T-cell influence. Shock. 2011; 36(2):162-9.

 

Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31(5):1100-7.

 

Hanschen M, Tajima G, O’Leary F, Ikeda K, Lederer JA. Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells. Shock. 2011; 35(3):252-7.

 

MacConmara MP, Tajima G, O’Leary F, Delisle AJ, McKenna AM, Stallwood CG, Mannick JA, Lederer JA. Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. Journal of Leukocyte Biology. 2011; 89(1):137-47.

 

Whelan MC, Casey G, MacConmara M, Lederer JA, Soden D, Collins JK, Tangney M, O’Sullivan GC. Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation. Cancer Gene Therapy. 2010; 17(7):501-11.

 

Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG 2nd, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O’Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(22):9923-8.

 

Evans HL, Cuschieri J, Moore EE, Shapiro MB, Nathens AB, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, West MA. Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. The Journal of Trauma. 2009; 67(2):384-8.

 

Fujimi S, Lapchak PH, Zang Y, MacConmara MP, Maung AA, Delisle AJ, Mannick JA, Lederer JA. Murine dendritic cell antigen-presenting cell function is not altered by burn injury. Journal of Leukocyte Biology. 2009; 85(5):862-70.

 

Kawasaki T, Choudhry MA, Schwacha MG, Fujimi S, Lederer JA, Bland KI, Chaudry IH. Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process. Cell Physiology. 2008; 294(3):C754-64.

 

Lederer JA, Brownstein BH, Lopez MC, Macmillan S, Delisle AJ, Macconmara MP, Choudhry MA, Xiao W, Lekousi S, Cobb JP, Baker HV, Mannick JA, Chaudry IH. Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiological Genomics. 2008; 32(3):299-310.

 

Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury enhances resistance to Escherichia coli infection by boosting innate immune system function. Journal of Immunology. 2008; 180(4):2450-8.

 

Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006; 114(19):2047-55.

 

MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity. Annals of Surgery. 2006; 244(4):514-23.

 

Kawasaki T, Fujimi S, Lederer JA, Hubbard WJ, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice. Journal of Immunology. 2006; 177(7):4514-20.

 

Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood. 2006; 107(11):4399-406.

 

Brownstein BH, Logvinenko T, Lederer JA, Cobb JP, Hubbard WJ, Chaudry IH, Remick DG, Baker HV, Xiao W, Mannick JA. Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiological Genomics. 2006; 24(3):298-309.

 

Purcell EM, Dolan SM, Kriynovich S, Mannick JA, Lederer JA. Burn injury induces an early activation response by lymph node CD4+ T cells. Shock. 2006; 25(2):135-40.

 

Ni Choileain N, MacConmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA. Enhanced regulatory T cell activity is an element of the host response to injury. Journal of Immunology. 2006; 176(1):225-36.

 

MacConmara M, Lederer JA. B cells. Critical Care Medicine. 2005; 33(12 Suppl):S514-6.

 

Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal of Leukocyte Biology. 2005; 78(2):565-73.

 

Lederer JA. Does nitric oxide control the counter-inflammatory response in endotoxic shock? Critical Care Medicine. 2005; 33(4):896-8.

 

Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O’keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(13):4801-6.

 

Murphy TJ, Ni Choileain N, Zang Y, Mannick JA, Lederer JA. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. Journal of Immunology. 2005; 174(5):2957-63.

 

Murphy TJ, Paterson HM, Kriynovich S, Zang Y, Kurt-Jones EA, Mannick JA, Lederer JA. Linking the “two-hit” response following injury to enhanced TLR4 reactivity. Journal of Leukocyte Biology. 2005; 77(1):16-23.

 

Zang Y, Dolan SM, Ni Choileain N, Kriynovich SJ, Murphy TJ, Sayles P, Mannick JA, Lederer JA. Burn injury initiates a shift in superantigen-induced T cell responses and host survival. Journal of Immunology. 2004; 172(8):4883-92.

 

Murphy TJ, Paterson HM, Mannick JA, Lederer JA. Injury, sepsis, and the regulation of Toll-like receptor responses. Journal of Leukocyte Biology. 2004; 75(3):400-7.

 

Guo Z, Kavanagh E, Zang Y, Dolan SM, Kriynovich SJ, Mannick JA, Lederer JA. Burn injury promotes antigen-driven Th2-type responses in vivo. Journal of Immunology. 2003; 171(8):3983-90.

 

Murphy T, Paterson H, Rogers S, Mannick JA, Lederer JA. Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients. Annals of Surgery. 2003; 238(3):401-10; discussion 410-1.

 

Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, Mannick JA, Lederer JA. Injury primes the innate immune system for enhanced Toll-like receptor reactivity. Journal of Immunology. 2003; 171(3):1473-83.

 

Shelley O, Murphy T, Paterson H, Mannick JA, Lederer JA. Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury. Shock. 2003; 20(2):123-9.

 

Shelley O, Murphy T, Lederer JA, Mannick JA, Rodrick ML. Mast cells and resistance to peritoneal sepsis after burn injury. Shock. 2003; 19(6):513-8.

 

Mueller TF, Ma C, Lederer JA, Perkins DL. Differentiation of stress, metabolism, communication, and defense responses following transplantation. Journal of Leukocyte Biology. 2003; 73(3):379-90.

 

Mannick JA, Rodrick ML, Lederer JA. The immunologic response to injury. Journal of the American College of Surgeons. 2001; 193(3):237-44.

 

O’Suilleabhain CB, Kim S, Rodrick MR, Mannick JA, Lederer JA. Injury induces alterations in T-cell NFkappaB and AP-1 activation. Shock. 2001; 15(6):432-7.

 

Kell MR, Shelley O, Mannick JA, Guo Z, Lederer JA. A central role for CD95 (Fas) in T-cell reactivity after injury. Surgery. 2000; 128(2):159-64.

 

Göebel A, Kavanagh E, Lyons A, Saporoschetz IB, Soberg C, Lederer JA, Mannick JA, Rodrick ML. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Annals of Surgery. 2000; 231(2):253-61.

 

Lyons A, Goebel A, Mannick JA, Lederer JA. Protective effects of early interleukin 10 antagonism on injury-induced immune dysfunction. Archives of Surgery. 1999; 134(12):1317-23; discussion 1324.

 

Kavanagh EK, Kell MR, Goebel A, Soberg CC, Mannick JA, Lederer JA. Interleukin 10 is not essential for survival or for modulating T-cell function after injury. Surgery. 1999; 126(2):456-62.

 

Kell MR, Kavanaugh EG, Goebel A, Soberg CC, Lederer JA. Injury primes the immune system for an enhanced and lethal T-cell response against bacterial superantigen. Shock. 1999; 12(2):139-44.

 

Sadanaga N, Nagoshi M, Lederer JA, Joo HG, Eberlein TJ, Goedegebuure PS. Local secretion of IFN-gamma induces an antitumor response: comparison between T cells plus IL-2 and IFN-gamma transfected tumor cells. Journal of Immunotherapy. 1999; 22(4):315-23.

 

Kelly JL, O’Suilleabhain CB, Soberg CC, Mannick JA, Lederer JA. Severe injury triggers antigen-specific T-helper cell dysfunction. Shock. 1999; 12(1):39-45.

 

Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock. 1999; 11(3):153-9.

 

Mark DA, Donovan CE, De Sanctis GT, Krinzman SJ, Kobzik L, Linsley PS, Sayegh MH, Lederer J, Perkins DL, Finn PW. Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. International Immunology. 1998; 10(11):1647-55.

 

Kavanagh EG, Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA. Burn injury primes naive CD4+ T cells for an augmented T-helper 1 response. Surgery. 1998; 124(2):269-76; discussion 276-7.

 

Behar SM, Roy C, Lederer J, Fraser P, Brenner MB. Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive. Arthritis and Rheumatism. 1998; 41(3):498-506.

 

Lyons A, Kelly JL, Rodrick ML, Mannick JA, Lederer JA. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. Annals of Surgery. 1997; 226(4):450-8; discussion 458-60.

 

Kelly JL, Lyons A, Soberg CC, Mannick JA, Lederer JA. Anti-interleukin-10 antibody restores burn-induced defects in T-cell function. Surgery. 1997; 122(2):146-52.

 

Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 defines a novel T cell costimulatory pathway. Journal of Immunology. 1997; 158(10):4548-54.

 

Lederer JA, Perez VL, DesRoches L, Kim SM, Abbas AK, Lichtman AH. Cytokine transcriptional events during helper T cell subset differentiation. The Journal of Experimental Medicine. 1996; 184(2):397-406.

 

O’Suilleabhain C, O’Sullivan ST, Kelly JL, Lederer J, Mannick JA, Rodrick ML. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery. 1996; 120(2):290-6.

 

Lederer JA, Liou JS, Kim S, Rice N, Lichtman AH. Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. Journal of Immunology. 1996; 156(1):56-63.

 

Borriello F, Lederer J. Construction of quantitative RT-PCR MIMICs. BioTechniques. 1995; 19(4):580-2, 584.

 

O’Sullivan ST, Lederer JA, Horgan AF, Chin DH, Mannick JA, Rodrick ML. Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Annals of Surgery. 1995; 222(4):482-90; discussion 490-2.

 

Perez VL, Lederer JA, Carniel E, Lichtman A, Abbas AK. The role of IL12 in helper T-cell differentiation. Research in Immunology. 1995; 146(7-8):477-80.

 

Briscoe DM, DesRoches LE, Kiely JM, Lederer JA, Lichtman AH. Antigen-dependent activation of T helper cell subsets by endothelium. Transplantation. 1995; 59(11):1638-41.

 

Perez VL, Lederer JA, Lichtman AH, Abbas AK. Stability of Th1 and Th2 populations. International Immunology. 1995; 7(5):869-75.

 

Young HA, Ghosh P, Ye J, Lederer J, Lichtman A, Gerard JR, Penix L, Wilson CB, Melvin AJ, McGurn ME. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. Journal of Immunology. 1994; 153(8):3603-10.

 

Lederer JA, Czuprynski CJ. Species-specific binding of IL-1, but not the IL-1 receptor antagonist, by fibroblasts. Cytokine. 1994; 6(2):154-61.

 

Lederer JA, Liou JS, Todd MD, Glimcher LH, Lichtman AH. Regulation of cytokine gene expression in T helper cell subsets. Journal of Immunology. 1994; 152(1):77-86.

 

St Louis JD, Lederer JA, Lichtman AH. Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy. The Journal of Experimental Medicine. 1993; 178(5):1597-605.

 

Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. The Journal of Experimental Medicine. 1993; 177(6):1663-74.

 

Lederer J, Czuprynski C. Characterization and identification of interleukin-1 receptors on bovine fibroblasts. Molecular Immunology. 1993; 30(2):191-6.

 

Kenefick KB, Lederer JA, Schell RF, Czuprynski CJ. Borrelia burgdorferi stimulates release of interleukin-1 activity from bovine peripheral blood monocytes. Infection and Immunity. 1992; 60(9):3630-4.

 

Lederer JA, Czuprynski CJ. Characterization and identification of interleukin 1 receptors on bovine neutrophils. Journal of Leukocyte Biology. 1992; 51(6):586-90.

 

Lederer JA, Czuprynski CJ. Species preference of bovine thymocytes and fibroblasts for bovine interleukin 1. Veterinary Immunology and Immunopathology. 1989; 23(3-4):213-22.

 

Lederer JA, Czuprynski CJ. Production and purification of bovine monocyte-derived interleukin 1. Veterinary Immunology and Immunopathology. 1989; 23(3-4):201-11.

 

Lederer JA, Brown JF, Czuprynski CJ. “Haemophilus somnus,” a facultative intracellular pathogen of bovine mononuclear phagocytes. Infection and Immunity. 1987; 55(2):381-7.